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The relationship between regional microstructural abnormalities of the corpus callosum and physical and cognitive disability in relapsing–remitting multiple sclerosis

机译:复发性多发性硬化症中call体局部微结构异常与身体和认知障碍之间的关系

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摘要

Significant corpus callosum (CC) involvement has been found in relapsing–remitting multiple sclerosis (RRMS), even if conventional magnetic resonance imaging measures have shown poor correlation with clinical disability measures. In this work, we tested the potential of multimodal imaging of the entire CC to explain physical and cognitive disability in 47 patients with RRMS. Values of thickness, fractional anisotropy (FA) and mean diffusivity (MD) were extracted from 50 regions of interest (ROIs) sampled along the bundle. The relationships between clinical, neuropsychological and imaging variables were assessed by using Spearman's correlation. Multiple linear regression analysis was employed in order to identify the relative importance of imaging metrics in modeling different clinical variables. Regional fiber composition of the CC differentially explained the response variables (Expanded Disability Status Scale [EDSS], cognitive impairment). Increases in EDSS were explained by reductions in CC thickness and MD. Cognitive impairment was mainly explained by FA reductions in the genu and splenium. Regional CC imaging properties differentially explained disability within RRMS patients revealing strong, distinct patterns of correlation with clinical and cognitive status of patients affected by this specific clinical phenotype.
机译:即使复发性多发性硬化症(RRMS)中也发现了重要的call体(CC)参与,即使常规的磁共振成像措施与临床残疾措施之间的相关性也很差。在这项工作中,我们测试了整个CC多模态成像的潜力,以解释47例RRMS患者的身体和认知残疾。从沿束采样的50个感兴趣区域(ROI)中提取厚度,分数各向异性(FA)和平均扩散率(MD)的值。使用Spearman的相关性评估临床,神经心理学和影像学变量之间的关系。为了确定成像指标在模拟不同临床变量中的相对重要性,采用了多元线性回归分析。 CC的区域纤维成分以差异方式解释了反应变量(扩展残疾状态量表[EDSS],认知障碍)。 EDSS的增加可以通过减少CC厚度和MD来解释。认知障碍的主要原因是足部和脾脏中FA的减少。区域CC成像特性以不同的方式解释了RRMS患者中的残疾,揭示了与受此特定临床表型影响的患者的临床和认知状况相关的强而独特的模式。

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