P04.49 The evaluation of anti cancer activity of isothiourea derivatives and CK2 inhibitors on cell lines of human glial tumor in vitro

摘要

BackgroundGliomas account for approximately 40% of all central nervous system tumours. Tumour progression is considered to be related to uncontrolled intracellular signal transduction pathways, including proteins kinases. Kinase activation plays an important role in cell viability and proliferation. Thus, the development of novel protein kinase inhibitors might lead to beneficial therapies in cancers. Two class of compounds: Caseine Kinase II inhibitors and isothiourea derivatives (ZKKs) are promising drugs with anticancer activity. CK2 is serine-threonine kinase that plays an important role in key cellular processes, including the cell cycle and resistance to apoptosis. ZKKs, such as N,N, -dimethyl -S-2,3,4,5,6-pentabromobenzylisothiouronium bromides, also inhibit the activity of various proteins. In the previous studies we have documented the cytotoxic effect of selected CK2 inhibitors and ZKKs. The present study was undertaken to continue the research on anti-cancer effect of isothiourea derivatives and CK2 inhibitors on the cell lines of glia-derived human tumours of different histological malignancy.