Design, Synthesis and Evaluation of Antitumor Activity against Human Cancer Cell Lines,Sansalvamide Analogues

摘要

@@ Sansalvamide A[1] (1) is a cyclic depsipeptide produced by a marine fungus of the genus Fusarium (Fusarium ssp.), this compound was found to possess significant cancer cell cytotoxicity. We have synthesized the corresponding cyclic peptide[2] of sansalvamide A (2), which is the amide derivative of sansalvamide A. Previous work of our group demonstrated that the antitumor activity of peptide sansalvamide A (2) is ten times more potent than Sansalvamide A (1), and the N-methylation of amino acid is also effect on antitumor activity, such as compound (3)[3] (Figure 1).