Two New Flavonoids from the Nuts of Areca catechu

摘要

Two new flavonoids, calquiquelignan M (>1), calquiquelignan N (>2), along with nine known compounds (>3–>11), were isolated from the nuts of Areca catechu (Palmae). The new structures, including absolute configurations, were established by a combination of spectroscopic data and electronic circular dichroism (ECD) calculation. The known compounds were identified by comparing their spectroscopic data with reported in the literature. The flavonoids compounds (>1–>8) were evaluated for their cytotoxicity activities against three human cancer cell lines. Compounds >1 and >2 exhibited a moderate cytotoxic activity against HepG2 cell lines with IC50 values of 49.8 and 53.6 μM, respectively.