Aging Affects the Association Between Endothelial Nitric Oxide Synthase Gene Polymorphism and Acute Myocardial Infarction in the Korean Male Population

摘要

ObjectivesThe aging process affects responsiveness and other functions of endothelium and vascular smooth muscle cells, predisposing the old vessels to the development of atherosclerotic lesions. Endothelial nitric oxide synthase (ecNOS) gene polymorphisms were shown to affect the occurrence of acute myocardial infarction (AMI). We hypothesized that aging may affect the association between the ecNOS gene polymorphism and AMI.