Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells

摘要

Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds >1–>3), were isolated along with ten known compounds >4–>13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of >1–>3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds >1–>13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ25–25), respectively. As a result, germacrane-type sesquiterpenoids >1–>4 and lignans >5–>7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.