Koenigs-Knorr Synthesis of Cycloalkyl Glycosides

摘要

Cadmium carbonate was found to be a useful promoter in the Koenigs-Knorr synthesis of 2-(4-methoxybenzyl)cyclohexyl-β-d-glycopyranosides. Using this promoter model glucoside and galactoside derivatives of cyclic (i.e., secondary) alcohols were synthesized in 50–60 % overall yields. Diastereoisomeric mixtures of products were obtained in these syntheses, which started from racemic isomers of 2-(4-methoxy-benzyl)cyclohexanol. The prepared compounds have been purified and characterized by their ¹H- and ¹³C-NMR spectra, as well as by their IR and MS spectra, in order to use them as reference compounds in planned subsequent research.