Hypoxia-Inducible Factor-1α (HIF-1α) Promotes Hypoxia-Induced Invasion and Metastasis in Ovarian Cancer by Targeting Matrix Metallopeptidase 13 (MMP13)

机译：低氧诱导因子-1α（HIF-1α）通过靶向基质金属肽酶13（MMP13）促进低氧诱导的卵巢癌侵袭和转移

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BackgroundHypoxia promotes cancer progression. Hypoxia-inducible factor-1α (HIF-1α) has been reported to enhance tumor invasion and metastasis via activating downstream genes, such as matrix metalloproteinases (MMPs). The purpose of this study was to explore the probable roles of HIF-1α and MMP13 in the invasion and metastasis of ovarian cancer under hypoxic conditions.

机译：背景低氧促进癌症进展。据报道，低氧诱导因子-1α（HIF-1α）通过激活下游基因，例如基质金属蛋白酶（MMPs）来增强肿瘤的侵袭和转移能力。这项研究的目的是探讨缺氧条件下HIF-1α和MMP13在卵巢癌的侵袭和转移中的可能作用。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Hui Zhang; Qingju Yang; Xuanye Lian; Ping Jiang; Jing Cui;
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作者单位

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年(卷),期 2019(25),-1
年度 2019
页码 7202–7208
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
Cell Hypoxia Neoplasm Invasiveness Neoplasm Metastasis Ovarian Neoplasms;

机译：细胞缺氧;肿瘤浸润;肿瘤转移;卵巢肿瘤;

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专利

1. MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1???±) in the tumor microenvironments MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1???±) in the tumor microenvironments MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1???±) in the tumor microenvironments [J] . Xuejun Gong, Yebin Lu, Wei Wei, Biology Open . 2017,第2期

机译：MiR-142通过在肿瘤微环境中靶向缺氧诱导因子1（HIF-1 ???±）来调节人胰腺癌的增殖和侵袭MiR-142通过靶向低氧诱导因子1（HIF-在肿瘤微环境中的1 ???±）MiR-142通过在肿瘤微环境中靶向缺氧诱导因子1（HIF-1 ???±）来调节人胰腺癌的增殖和侵袭。
2. Oridonin inhibits hypoxia-induced epithelial-mesenchymal transition and cell migration by the hypoxia-inducible factor-1 alpha/matrix metallopeptidase-9 signal pathway in gallbladder cancer [J] . Chen Kunlun, Ye Jianwen, Qi Lei, Anti-cancer drugs . 2019,第9期

机译：Oridonin抑制缺氧诱导的上皮 - 间充质转变和细胞迁移通过胆囊癌中的缺氧诱导因子-1α/基质金属肽酶-9信号途径
3. Aldose Reductase Inhibition Prevents Hypoxia-induced Increase in Hypoxia-inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor (VEGF) by Regulating 26 S Proteasome-mediated Protein Degradation in Human Colon Cancer Cells [J] . Ravinder Tammali, Ashish Saxena, Satish Srivastava, The Journal of biological chemistry . 2011,第27期

机译：醛糖还原酶抑制通过调节人结肠癌细胞中的26秒的蛋白酶体介导的蛋白质降解，防止缺氧诱导的缺氧诱导因子-1α（HIF-1α）和血管内皮生长因子（VEGF）的增加
4. SOR-C13, a Novel Cancer Peptide Therapeutic Targeting the TRPV6 Oncochannel Shows Efficacy in Breast and Ovarian Cancer Xenografts in a Murine Model [C] . Jack M. Stewart, Christopher Rice, Dominique Dugourd, PEGS . 2015

机译：SOR-C13，一种靶向TRPV6 oncoChannel的新型癌症肽治疗性靶向鼠模型中的乳腺癌和卵巢癌异种移植物的疗效
5. Inhibition of breast cancer angiogenesis and metastasis by targeting hypoxia-inducible factor 1alpha [D] . Madu, Chikezie O. 2012

机译：通过靶向缺氧诱导因子1alpha抑制乳腺癌血管生成和转移
6. Golgi Membrane Protein 1 (GOLM1) Promotes Growth and Metastasis of Breast Cancer Cells via Regulating Matrix Metalloproteinase-13 (MMP13) [O] . Rui Zhang, Zhi Zhu, Wenzhuang Shen, 2019

机译：高尔基体膜蛋白1（GOLM1）通过调节基质金属蛋白酶-13（MMP13）促进乳腺癌细胞的生长和转移。
7. Aldose Reductase Inhibition Prevents Hypoxia-induced Increase in Hypoxia-inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor (VEGF) by Regulating 26 S Proteasome-mediated Protein Degradation in Human Colon Cancer Cells* [O] . Tammali, Ravinder, Saxena, Ashish, Srivastava, Satish K., 2011

机译：醛糖还原酶抑制通过调节人结肠癌细胞中26 S蛋白酶体介导的蛋白质降解，防止低氧诱导的低氧诱导因子1α（HIF-1α）和血管内皮生长因子（VEGF）的增加*

Hypoxia-Inducible Factor-1α (HIF-1α) Promotes Hypoxia-Induced Invasion and Metastasis in Ovarian Cancer by Targeting Matrix Metallopeptidase 13 (MMP13)

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