Effects of different interchain linkers on biological activity of an anti-prostate cancer single-chain bispecific antibody

机译：不同链间连接子对抗前列腺癌单链双特异性抗体生物学活性的影响

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BackgroundA single-chain bispecific antibody (scBsAb; an engineered antibody), has promising clinical applications. Nonetheless, the effect of different interchain linkers on its activity is poorly understood.

机译：背景技术单链双特异性抗体（scBsAb；工程抗体）具有广阔的临床应用前景。然而，人们对不同链间连接子对其活性的影响了解甚少。

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期刊名称 Theoretical Biology Medical Modelling
作者
Chao-hui Hao; Qian-he Han; Zhong-jie Shan; Jian-ting Hu; Nan Zhang; Xue-pei Zhang;
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作者单位

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年(卷),期 2015(12),-1
年度 2015
页码 14
总页数 10
原文格式 PDF
正文语种
中图分类生物学;
关键词
Interchain linker Anti-γ-seminoprotein Anti-CD3 scBsAb Prostate cancer Biological activity;

机译：链间连接子;抗γ-丝氨酸蛋白;抗CD3;scBsAb;前列腺癌;生物活性;

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专利

1. 抗人卵巢癌/抗人CD3单链双特异性抗体的生物学活性研究 [J] . 杨介钻, 张众, 马骊, 癌症（英文版） . 2005,第007期
2. Effects of different interchain linkers on biological activity of an anti-prostate cancer single-chain bispecific antibody [J] . Chao-hui Hao, Qian-he Han, Zhong-jie Shan, Theoretical Biology and Medical Modelling . 2015,第1期

机译：不同链间连接子对抗前列腺癌单链双特异性抗体生物学活性的影响
3. Effects of interlinker sequences on the biological properties of bispecific single-chain antibodies [J] . FANG Min, JIANG Xin, YANG Zhi, Chinese science bulletin . 2003,第21期

机译：互连序列对双特异性单链抗体生物学特性的影响
4. Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody [J] . Le Gall F, Reusch U, Little M, Protein engineering design & selection: PEDS . 2004,第4期

机译：抗体可变结构域之间的接头序列对双特异性串联双抗体的形成，稳定性和生物学活性的影响
5. Identification of Pyroglutamate and O-linked Glycosylation on Anti-IL17A Peptide Anti-IL22 Antibody Bispecific Genetic Fusion [C] . Eric Sousa, Xiaotian Zhong, Elizabeth Kieras, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：抗IL17A肽抗IL22抗体双特异性遗传融合鉴定吡葡酸酯和O型糖基化的鉴定
6. Genetically Engineered Bispecific Antibodies for Cancer Pretargeting using the Irreversible Probe Capturing mAb 2D12.5 G54C. [D] . Beck, Heather Elizabeth. 2012

机译：使用不可逆探针捕获mAb 2D12.5 G54C进行癌症预靶向的基因工程双特异性抗体。
7. In vitro and in vivo activity of IMGN853 an Antibody-Drug Conjugate targeting Folate Receptor Alpha linked to DM4 in biologically aggressive endometrial cancers [O] . Gary Altwerger, Elena Bonazzoli, Stefania Bellone, -1

机译：IMGN853（一种靶向叶酸受体的抗体-药物偶联物与DM4连接）在生物侵袭性子宫内膜癌中的体外和体内活性
8. Effects of different interchain linkers on biological activity of an anti-prostate cancer single-chain bispecific antibody [O] . Chao-hui Hao, Qian-he Han, Zhong-jie Shan, 2015

机译：不同链间连接子对抗前列腺癌单链双特异性抗体生物学活性的影响
9. Cell Penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer. [R] . Lilly, M., Weisbart, R. 2016

机译：细胞穿透双特异性抗体靶向晚期前列腺癌的致癌转录因子。

Effects of different interchain linkers on biological activity of an anti-prostate cancer single-chain bispecific antibody

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