Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice

摘要

BackgroundProgrammed cell death or apoptosis is an essential process for tissue homeostasis. Hepatocyte apoptosis is a common mechanism to many forms of liver disease. This study was undertaken to test the role of ILK in hepatocyte survival and response to injury using a Jo-2-induced apoptosis model.