Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers

机译：伐尼克兰水杨酸即时释放片剂的配方及在人体志愿者中的药代动力学比较

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摘要

PurposeTo develop an immediate release-type tablet containing varenicline salicylate (VRC-S), a smoking cessation agent, formulation and stability studies were performed. The in vitro dissolution and in vivo pharmacokinetic (PK) behavior of the tablets were compared with those of the commercial product (Champix) as a reference.

机译：目的为了开发一种包含缬草酸水杨酸（VRC-S），戒烟剂的速释型片剂，进行了制剂和稳定性研究。将片剂的体外溶出度和体内药代动力学（PK）行为与作为参考的商业产品（Champix）进行比较。

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期刊名称 Drug Design Development and Therapy
作者
Seong Shin Kwak; Eun Seok Lee; Ho Yub Yoon; Chang Hyun Kim; Yoon Tae Goo; Myung Joo Kang; Sangkil Lee; Bong Sang Lee; Hong Ryeol Jeon; Chang Hyun Oh; Young Wook Choi;
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作者单位

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年(卷),期 2018(12),-1
年度 2018
页码 3377–3392
总页数 16
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
varenicline salicylate smoking cessation formulation stability dissolution bioavailability;

机译：伐尼克兰水杨酸酯;戒烟;剂型;稳定性;溶出度;生物利用度;

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专利

1. Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers [J] . Seong Shin Kwak, Eun Seok Lee, Ho Yub Yoon, Drug Design, Development and Therapy . 2018,第InaProgress期

机译：伐尼克兰水杨酸即时释放片剂的配方及在人体志愿者中的药代动力学比较
2. Pharmacokinetic comparison of a new sustained-release formulation of glimepiride/metformin 1/500 mg combination tablet and a sustained-release formulation of glimepiride/metformin 2/500 mg combination tablet in healthy Korean male volunteers: a randomized, 2-sequence, 2-period, 2-treatment crossover study. [J] . Shin KH, Kim SE, Yoon SH, Clinical therapeutics . 2011,第11期

机译：新型格列美脲/二甲双胍1/500 mg组合片剂的缓释制剂与格列美脲/二甲双胍2/500 mg组合片剂的缓释制剂在健康的韩国男性志愿者中的药代动力学比较：随机，2序列，2期间，进行2次治疗交叉研究。
3. Promising Swellable Floating Bupropion Tablets: Formulation, in vitro/in vivo Evaluation and Comparative Pharmacokinetic Study in Human Volunteers [J] . Mahmoud Teaima, Magdi M. Abdel Hamid, Nabil A. Shoman, Drug Design, Development and Therapy . 2020,第1期

机译：有前途的脱脂浮绒平片：制剂，体外/体内评价和人类志愿者的比较药代动力学研究
4. Pharmacokinetic Studies with a Mucoadhesive Multilayer Extended-Release Tablet Formulation ofLevodopa-Carbidopa in Healthy Volunteers [C] . Peyman Moslemy, Bennett Carter, Nicholas Cardoso, Controlled Release Society Annual Meeting and Exposition . 2007

机译：左旋多巴-卡比多巴的粘膜粘附多层延长释放片制剂在健康志愿者中的药代动力学研究。
5. 1. Development of hot-melt pan-coating, application to sustained-release capsules and tamper resistant-coating. 2. Formulation of verapamil hydrogen chloride and diltiazem hydrogen chloride semisolid matrix capsules. 3. Novel sustained release tablet of glipizide: Compression of coated drug beads, formulation, dissolution, and convolution. 4. Verapamil sustained release: New formulation and convolution. [D] . Nguyen, Chien Ngoc. 2006

机译：1.开发热熔性包衣，应用于缓释胶囊和防篡改包衣。 2.配制维拉帕米氯化氢和地尔硫卓氯化氢半固体基质胶囊。 3.格列吡嗪的新型缓释片剂：包衣药物珠的压缩，制剂，溶解和卷积。 4.维拉帕米缓释剂：新配方和卷积剂。
6. Promising Swellable Floating Bupropion Tablets: Formulation in vitro/in vivo Evaluation and Comparative Pharmacokinetic Study in Human Volunteers [O] . Mahmoud Teaima, Magdi M. Abdel Hamid, Nabil A. Shoman, 2020

机译：有前途的脱脂浮绒平片：制剂体外/体内评价和人类志愿者的比较药代动力学研究
7. Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers [O] . Seong Shin Kwak, Eun Seok Lee, Ho Yub Yoon, 2018

机译：立即释放片剂制剂瓦宁林水杨酸和人类志愿者的比较药代动力学研究

Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers

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