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Immediate-release tablet formulation, composition for tablets and method for manufacturing immediate-release tablet formulation

机译:速释片剂制剂,片剂组合物和制造速释片剂制剂的方法

摘要

There are provided a tablet-form immediate-release preparation that contains a high concentration of a casein and/or a casein hydrolysate as an active ingredient but has an excellent physical strength, a composition for the preparation that has an excellent tabletability, and a method for producing the preparation from the composition. Each of the preparation and the composition contains 50% by mass or more of the casein and/or the casein hydrolysate, and further contains a lactose having a volume average particle diameter of not less than 50 μm and not more than 300 μm. The content of the lactose is 6.0 to 100 parts by mass per 100 parts by mass of the casein and/or the casein hydrolysate. The method for producing the preparation contains the steps of: preparing a mixture as the composition; filling a mortar with the mixture and tableting the mixture; and separating the tableted mixture from the mortar.
机译:提供了一种片剂形式的速释制剂,其包含高浓度的酪蛋白和/或酪蛋白水解产物作为活性成分,但是具有优异的物理强度,该制剂的组合物具有优异的压片性,以及方法用于由组合物生产制剂。每种制剂和组合物均包含50质量%以上的酪蛋白和/或酪蛋白水解物,并且还包含体积平均粒径不小于50μm且不大于300μm的乳糖。乳糖的含量相对于100质量份酪蛋白和/或酪蛋白水解物为6.0〜100质量份。制备制剂的方法包括以下步骤:制备混合物作为组合物;用混合物填充研钵并压片混合物;并从研钵中分离出片剂混合物。

著录项

  • 公开/公告号US9675666B2

    专利类型

  • 公开/公告日2017-06-13

    原文格式PDF

  • 申请/专利权人 ASAHI CALPIS WELLNESS CO. LTD.;

    申请/专利号US201515315805

  • 发明设计人 AKIRA KUBOTA;

    申请日2015-06-03

  • 分类号A61K9/14;A61K31/337;A61K38/17;A61K9/20;A61K38/01;

  • 国家 US

  • 入库时间 2022-08-21 13:46:29

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