5-(Thiophen-2-yl)-134-thiadiazole derivatives: synthesis molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents

摘要

BackgroundNowadays, cancer is an important public health problem in all countries. Limitations of current chemotherapy for neoplastic diseases such as severe adverse reactions and tumor resistance to the chemotherapeutic drugs have been led to a temptation for focusing on the discovery and development of new compounds with potential anticancer activity. The importance of thiophene and thiadiazole rings as scaffolds present in a wide range of therapeutic agents has been well reported and has driven the synthesis of a large number of novel antitumor agents.