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New approaches to management of neonatal hypoglycemia

机译:新生儿低血糖治疗的新方法

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摘要

Despite being a very common problem after birth, consensus on how to manage low glucose concentrations in the first 48 h of life has been difficult to establish and remains a debated issue. One of the reasons for this is that few studies have provided the type of data needed to establish a definitive approach agreed upon by all. However, some recent publications have provided much needed primary data to inform this debate. These publications have focused on aspects of managing low blood glucose concentrations in the patients most at-risk for asymptomatic hypoglycemia—those born late-preterm, large for gestational age, small for gestational age, or growth restricted, and those born following a pregnancy complicated by diabetes mellitus. The goal of this review is to discuss specific aspects of this new research. First, we focus on promising new data testing the role of buccal dextrose gel in the management of asymptomatic neonatal hypoglycemia. Second, we highlight some of the clinical implications of a large, prospective study documenting the association of specific glycemic patterns with neurodevelopmental outcomes at two years of age.
机译:尽管出生后是一个非常普遍的问题,但关于如何在生命的头48小时内控制低血糖浓度的共识仍然难以建立,仍然是一个有争议的问题。原因之一是很少有研究提供建立所有人都同意的确定方法所需的数据类型。但是,最近的一些出版物提供了急需的主要数据来为这场辩论提供信息。这些出版物侧重于控制无症状低血糖风险最高的患者中的低血糖浓度的方面,这些患者是早产,大胎龄,小胎龄或生长受限的人,以及那些因复杂妊娠而出生的人。通过糖尿病。这篇综述的目的是讨论这项新研究的特定方面。首先,我们集中于有希望的新数据,以测试口腔右旋糖凝胶在无症状新生儿低血糖管理中的作用。其次,我们重点介绍了一项大型的前瞻性研究的一些临床意义,该研究记录了特定的血糖模式与两岁时的神经发育结果的关联。

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