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Mast cells and hypoxia drive tissue metaplasia and heterotopic ossification in idiopathic arthrofibrosis after total knee arthroplasty

机译:全膝关节置换术后特发性关节炎纤维化中肥大细胞和缺氧驱动组织化生和异位骨化

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摘要

BackgroundIdiopathic arthrofibrosis occurs in 3-4% of patients who undergo total knee arthroplasty (TKA). However, little is known about the cellular or molecular changes involved in the onset or progression of this condition. To classify the histomorphologic changes and evaluate potential contributing factors, periarticular tissues from the knees of patients with arthrofibrosis were analyzed for fibroblast and mast cell proliferation, heterotopic ossification, cellular apoptosis, hypoxia and oxidative stress.
机译:背景:特发性关节纤维化发生在接受全膝关节置换术(TKA)的患者中,占3-4%。但是,对于这种病的发作或发展所涉及的细胞或分子变化知之甚少。为了对组织形态学变化进行分类并评估潜在的影响因素,对关节纤维化患者膝关节周围的组织进行了成纤维细胞和肥大细胞增殖,异位骨化,细胞凋亡,缺氧和氧化应激的分析。

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