Identification of susceptibility genes in non-syndromic cleft lip with or without cleft palate using whole-exome sequencing

摘要

BackgroundNon-syndromic cleft lip with or without cleft palate (NSCL/P) is among the most common congenital malformations. The etiology of NSCL/P remains poorly characterized owing to its complex genetic heterogeneity. The objective of this study was to identify genetic variants that increase susceptibility to NSCL/P.