The Signal Peptide Sequence Impacts the Immune Response Elicited by a DNA Epitope Vaccine

摘要

We examined the effect of two leader sequences, one from a transmembrane molecule (H2-L^d) and another from a secreted molecule (rat KC chemokine), on the immunogenicity of DNA epitope vaccines. The chemokine leader enhanced vaccine immunogenicity, thus underscoring the importance of the leader sequence in DNA epitope vaccine design.