Involvement of hypothalamic PI3K–STAT3 signalling in regulating appetite suppression mediated by amphetamine

摘要

BACKGROUND AND PURPOSEAppetite suppression induced by amphetamine has been attributed to its inhibition of neuropeptide Y (NPY) neurons and activation of pro-opiomelanocortin (POMC) neurons in the hypothalamus. This study examined whether STAT3 was involved in these actions of amphetamine.