Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate and farnesyl and geranylgeranyl transferase inhibitors

摘要

BACKGROUND AND PURPOSEProtein isoprenylation is an important step in the intracellular signalling pathway conducting cell growth and differentiation. In bone, protein isoprenylation is required for osteoclast differentiation and activation. However, its role in osteoblast differentiation and function remains unknown. In this study, we assessed the role of protein isoprenylation in osteoblastogenesis in a model of mesenchymal stem cells (MSC) differentiation.