Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents

摘要

Background and purpose:Mexiletine (Mex), an orally effective antiarrhythmic agent used to treat ventricular arrhythmias, has also been found to be effective for myotonia and neuropathic pain. It is extensively metabolized in humans but little information exists about the pharmacodynamic properties of its metabolites.