Systemic morphine produce antinociception mediated by spinal 5-HT7 but not 5-HT1A and 5-HT2 receptors in the spinal cord

机译：全身性吗啡会产生由脊髓5-HT7介导的镇痛作用但不会产生脊髓中的5-HT1A和5-HT2受体介导的镇痛作用

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Background and purpose:The serotonergic system within the spinal cord have been proposed to play an important role in the analgesic effects of systemic morphine. Currently, seven groups of 5-HT receptors (5-HT1–7) have been characterized. One of the most recently identified subtypes of 5 HT receptor is the 5-HT7 receptor. We aimed to examine the role of spinal 5-HT7 receptors in the antinociceptive effects of systemic morphine.

机译：背景与目的：已提出脊髓内的血清素能系统在全身性吗啡的镇痛作用中起重要作用。目前，已鉴定出七组5-HT受体（5-HT1–7）。 5-HT 7受体是最近鉴定出的5 HT受体亚型之一。我们旨在检查脊髓5-HT 7受体在全身性吗啡的抗伤害感受作用中的作用。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
A Dogrul; M Seyrek;
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作者单位

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年(卷),期 2006(149),5
年度 2006
页码 498–505
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
serotonin 5-HT7 receptor opioid descending pathways analgesia spinal cord;

机译：血清素;5-HT7受体;阿片类药物;下降途径;镇痛;脊髓;

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专利

1. Stimulation of the lateral hypothalamus produces antinociception mediated by 5-HT1A, 5-HT1B and 5-HT3 receptors in the rat spinal cord dorsal horn. [J] . Holden JE, Farah EN, Jeong Y Neuroscience: An International Journal under the Editorial Direction of IBRO . 2005,第4期

机译：下丘脑外侧的刺激产生由大鼠脊髓背角中的5-HT1A，5-HT1B和5-HT3受体介导的抗伤害感受。
2. Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors. [J] . Jean Liu, Allison R Reid, Jana Sawynok Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2013,第Null期

机译：通过全身性对乙酰氨基酚（扑热息痛）进行的抗伤害感受涉及脊髓5-羟色胺5-HT7和腺苷A1受体，以及外周腺苷A1受体。
3. Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline [J] . LiuJ., ReidA.R., SawynokJ. European Journal of Pharmacology: An International Journal . 2013,第1a3期

机译：脊髓5-羟色胺5-HT7和腺苷A1受体以及周围腺苷A1受体通过全身性给药阿米替林参与抗伤害感受
4. Synthes Award for Resident Research in Spinal Cord Spinal Column Injury: Surgical Repair of the Injured Spinal Cord Using Biodegradable Polymer Implants to Facilitate Axon Regeneration [C] . Jonathan A. Friedman, Eric B. Lewellyn, Michael J Moore Congress of Neurological Surgeons . 2004

机译：脊髓脊柱损伤驻留研究综合奖：使用可生物降解的聚合物植入物的受损脊髓的手术修复，以促进轴突再生
5. Acute downregulation of antibody production against antigens draining from the spinal subarachnoid space following spinal cord injury: Mediation by systemic catecholamines. [D] . Vega, Jose Luis. 2002

机译：脊髓损伤后针对从蛛网膜下腔排出的抗原的抗体产生的急性下调：由全身儿茶酚胺介导。
6. Activation of Opioid Receptor Like-1 Receptor in the Spinal Cord Produces Sex-Specific Antinociception in the Rat: Estrogen Attenuates Antinociception in the Female whereas Testosterone Is Required for the Expression of Antinociception in the Male [O] . Jomo Claiborne, Subodh Nag, Sukhbir S. Mokha 2006

机译：脊髓中阿片受体样-1受体的激活在大鼠中产生性别特异性镇痛作用：雌激素可减轻雌性镇痛作用而睾丸激素是雄性镇痛作用所必需的。
7. Systemic morphine produce antinociception mediated by spinal 5-HT7, but not 5-HT1A and 5-HT2 receptors in the spinal cord [O] . Dogrul, A, Seyrek, M 2006

机译：全身性吗啡会产生由脊髓5-HT7介导的镇痛作用，但不会产生脊髓中的5-HT1A和5-HT2受体介导的镇痛作用

Systemic morphine produce antinociception mediated by spinal 5-HT7 but not 5-HT1A and 5-HT2 receptors in the spinal cord

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