机译
作为复杂系统的大脑：使用网络科学作为了解大脑的工具
摘要：Although graph theory has been around since the 18th century, the field of network science is more recent and continues to gain popularity, particularly in the field of neuroimaging. The field was propelled forward when Watts and Strogatz introduced their small-world network model, which described a network that provided regional specialization with efficient global information transfer. This model is appealing to the study of brain connectivity, as the brain can be viewed as a system with various interacting regions that produce complex behaviors. In practice, graph metrics such as clustering coefficient, path length, and efficiency measures are often used to characterize system properties. Centrality metrics such as degree, betweenness, closeness, and eigenvector centrality determine critical areas within the network. Community structure is also essential for understanding network organization and topology. Network science has led to a paradigm shift in the neuroscientific community, but it should be viewed as more than a simple “tool du jour.” To fully appreciate the utility of network science, a greater understanding of how network models apply to the brain is needed. An integrated appraisal of multiple network analyses should be performed to better understand network structure rather than focusing on univariate comparisons to find significant group differences; indeed, such comparisons, popular with traditional functional magnetic resonance imaging analyses, are arguably no longer relevant with graph-theory based approaches. These methods necessitate a philosophical shift toward complexity science. In this context, when correctly applied and interpreted, network scientific methods have a chance to revolutionize the understanding of brain function.
