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High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

机译：高强度压缩通过p38 MAPK-ROS途径加速髓核细胞的过早衰老

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BackgroundMechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on NP cell senescence and the underlying molecular mechanism of this process.

机译：背景机械过载会导致光盘退化。变性椎间盘内髓核（NP）细胞衰老加剧。这项研究旨在调查高压缩对NP细胞衰老的影响以及该过程的潜在分子机制。

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期刊名称 Arthritis Research
作者
Pei Li; Gang Hou; Ruijie Zhang; Yibo Gan; Yuan Xu; Lei Song; Qiang Zhou;
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作者单位

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年(卷),期 2017(19),-1
年度 2017
页码 209
总页数 14
原文格式 PDF
正文语种
中图分类外科学;
关键词
Compression Senescence Nucleus pulposus cell p38 MAPK Reactive oxygen species;

机译：压缩;衰老;髓核细胞;p38 MAPK;活性氧;

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专利

1. High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway [J] . Pei Li, Gang Hou, Ruijie Zhang, Arthritis research & therapy. . 2017,第1期

机译：高强度压缩通过p38 MAPK-ROS途径加速髓核细胞的过早衰老
2. N-cadherin attenuates nucleus pulposus cell senescence under high-magnitude compression [J] . Niu Ming, Ma Fei, Qian Jun, Molecular medicine reports . 2018,第2aPta2期

机译：n-cadherin在高级别压缩下衰减核搏酸细胞衰老
3. Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells [J] . FengChencheng, YangMinghui, ZhangYang, International journal of molecular medicine . 2018,第6期

机译：循环机械张力增强DNA损伤并激活p53-p21-Rb途径，以诱导髓核细胞过早衰老
4. Lower Macromer Concentration Enhances Nucleus Pulposus-Like Differentiation and Functional Extracellular Matrix Assembly by Human Marrow-Derived Stromal Cells Encapsulated in Photocrosslinked Carboxymethylcellulose Hydrogels [C] . Gupta MS, Nicoll SB ASME summer bioengineering conference;SBC2012 . 2012

机译：较低的大分子单体浓度提高了髓核样分化和功能性细胞外基质组装的光致交联羧甲基纤维素水凝胶封装的人类骨髓基质细胞。
5. Effects of Design Factors and Microenvironment on Mesenchymal Stem Cells and Nucleus Pulposus Cells for Intervertebral Disc Tissue Engineering. [D] . Ouyang, Ann. 2017

机译：设计因素和微环境对间质干细胞和髓核细胞进行椎间盘组织工程的影响。
6. Role of p38–MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture [O] . Lianglong Pang, Pei Li, Ruijie Zhang, 2017

机译：p38–MAPK途径在椎间盘灌注培养中高强度压缩对髓核细胞衰老的影响中的作用
7. Role of p38–MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture [O] . Lianglong Pang, Pei Li, Ruijie Zhang, 2017

机译：P38-MAPK途径在椎间盘灌注培养中高尺寸压缩对核牙髓细胞衰老的作用

High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

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