Threshold for maximal electroshock seizures(MEST) at three developmental stages in young mice

摘要

Early brain development after birth is extremely dynamic,suggest!ng that potential functional changes occur during this period.In this study,the maximal electroshock seizure threshold(MEST)was used to explore the electrophysiological variation among three developmental stages in young mice(no more than 5 weeks old).The induced electroshock seizure(ES)behavior of early post natal mice(1-2-weeks old)differed from that during weaning(3 weeks old)and early puberty(4-5-weeks old).Thus,we further explored their respective characteristic responses to the ES parameters.When the stimulation current(SC)was limited to 4.0 mA,only the 1-2-week-old mice were induced to exhibit ES behavior at voltages of 30 V and 40 V,indicating they were more sensitive to maximal electroshock seizure(MES)(response to lower voltage).