微量白蛋白尿与代谢综合征及其组分的关系

摘要

目的 筛查普通人群微量白蛋白尿(MAU)的患病率,并分析代谢综合征(MS)不同组分与MAU的关系.方法 对进行体检的1 654例健康人群测定身高、体重、血压、空腹血糖、血脂、尿微量白蛋白和肌酐等指标,分组统计MAU的患病率及与MS各组分的关系.结果 MAU组年龄、体重指数、血压、空腹血糖和血脂水平均显著高于无MAU组.MAU在普通人群中的患病率为8.1%,随着年龄的增长,MAU的患病率有增高的趋势,60岁以后显著增高.各代谢异常组MAU的患病率显著增高,以MS组患病率最高,达20.7%.肥胖、高血压、高血糖、血脂紊乱和年龄是MAU发生的独立风险因素,OR值分别为3.11、2.99、2.54、1.62、1.22.结论 肥胖、高血压、高血糖、血脂紊乱和年龄是MAU发生的主要风险因素,对中老年人和代谢异常人群进行MAU的筛查是必要的.%To investigate the prevalence of microalbuminuria (MAU) and its association with metabolic syn-drome (MS) in general population.MethodsA total 1 654 subjects undergoing health check-up in Hangzhou city were selectedby multistage,clustered complex sampling method. The fasting glucose, blood lipids, urinary albumin, urinary creatinine and an-thropometric indices were measured. The association of MAU with MS and its components were examined by univariate and mul-tivariate logistic regression analysis.ResultsSubjects with MAU had higher age, BMI, blood pressure, fasting glucose andtriglycerides levels than those without MAU. The prevalence of MAU in this population was 8.1%. The incidence of MAU was increased with the age. The prevalence of MAU increased in subjects with metabolic abnormalities and for those with metabolic syndrome the incidence of MAU was 20.7%. Obesity, hypertension, hyperglycemia, hyperlipidemia and age were independent risk factors for MAU in both genders, the odds ratios were 3.11, 2.99, 2.54, 1.62 and 1.22, respectively.ConclusionObesity, highblood pressure, high blood lipids, high blood sugar and age are main risk factors causing MAU in general population.