To investigate the prevalence of metabolic syndrome (MS Jamong different age groups of womenwith polycystic ovary syndrome (PCOS).Three hundreds and thirty two women with polycystic ovary syndrome weredivided into group A (aged <20y), group B (aged 20-29y) and group C (aged &30y). The prevalence of MS, clinical manifestations, hormonal profile and metabolic abnormalities were compared among groups.ResultsThe prevalence rate of MSin groups A, B and C was 7.69%, 21.45% and 48.39%,respectively (P<0.005). BMI, blood pressure and the rate of acanthosis nigricans did not differ among three groups. The waist circumference and waist-hip rate (WHR) of group C was the highest. The levels of TG (1.58±0.75mmol/L), LDL-C (2.84 ±0.76 mmol/L)and FPG (4.84 ±0.70 mmol/L)of group C were highest, while the level of HDL-C of group C was lowest! P<0.05 Jamong three groups. However, no differences were observed in the levels of total testosterone (T), LH/FSH, 2hPG, fasting insulin (FIN), ISI and HOMA-IR. Among all components of MS, low serum HDL-C was the most common abnormality in all age groups, while high serum glucose was the least common one. The rates of low serum HDL-C and high serum glucose in group C were the highest, and those in group A were the lowest. No differences were found in the prevalence of hypertriglyceridemia and high blood pressure among three age groups.ConclusionPatients with PCOS in elderaged group have a higher prevalence of MS than that of younger group, which may be associated with central obesity, low serum HDL-C and high serum glucose in the elder patients.%目的 研究不同年龄多囊卵巢综合征(PCOS)患者合并代谢综合征(MS)的发生情况.方法 多囊卵巢综合征患者332例,按照年龄分A 组(<20 岁)、B 组(20~29 岁)、C 组(≥30 岁).比较3组患者中MS的发生率,MS 发生相关的各项临床特征、内分泌及代谢指标.结果 3组患者中MS 的患病率分别为7.69%、21.45%和48.39%(P<0.01).3组患者BMI、血压及黑棘皮征的发生无统计学差异,但腹围及腰臀比(WHR)差异存在统计学意义(均P<0.05).C 组患者TG[(1.58±0.75)mmol/L]、LDL-C[(2.84±0.76)mmol/L]、FPG[(4.84±0.70)mmol/L]最高,HDL-C[(1.27±0.30)mmol/L]最低,差异存在统计学意义(均P<0.05),而T、LH/FSH、2hPG、FIN、胰岛素敏感指数(ISI)、稳态模型IR 指数(HOMA-IR)3组间均无统计学差异.比较各组内MS各项指标(除腹围外)的发生率,HDL-C 降低在3 组患者中均是最高的,血糖异常在3组中均是最低的.而在3 组间比较MS 各项指标的发生率,结果示HDL-C 降低及血糖异常的发生C 组最高,A 组最低,差异存在统计学意义(均P<0.05),TG 升高及血压异常的发生在3 组间无统计学差异.结论 PCOS 患者中MS的患病率随年龄增大而增高.向心性肥胖、HDL-C降低、血糖异常的发生率增高是高年龄PCOS患者MS 患病率增加的主要原因.
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