目的：探讨短期极低碳水化合物饮食（VLCD ）干预对超重肥胖患者骨代谢指标的影响。方法：将205例超重或肥胖受试者以1：3比例随机分配至“单纯生活方式干预组”（对照组）和“单纯生活方式加VLCD干预组”（干预组）。比较2种不同干预方式在干预前后体重、体重指数（BMI ）、腰围及甲状旁腺素（PTH ）、β胶原特殊序列（β－CTx ）、总N端骨钙素（TNOC ）、I型前胶原氨基端延长肽（P1NP ）、25－羟化维生素D3[25－（OH ）－D3]的变化。结果：2种不同干预方式在干预后体重、BM I、腰围均较干预前明显下降，但VLCD治疗组在干预后下降较对照组明显（ P＜0.01）。2组干预前后骨代谢指标变化差异无统计学意义（ P＞0.05）。结论：短期VLCD护理对超重肥胖患者体重、BMI、腰围明显改善，对骨代谢指标总体无明显影响。%Objective] To investigate the effects of a short -term very low carbohydrate diet (VLCD) intervention on bone turnover of overweight and obese subjects .[Method] A total of 205 overweight or obese subjects were recruited and random-ized into control group and treatmeat groupwith a ratio of 1:3 .The control group received medical lifestyle intervention ,while the intervention group received very low carbohydrate diet intervention in addition to medical lifestyle intervention .Body weight , waist circumstance ,BMI ,Parathyroid hormone(PTH) ,β-crosslaps(β-CTx) ,N-terminal osteocalcin (TNOC) ,total pro-collagen I type N-terminal propeptide (P1NP ) and 25-OH-D3of each subjectwere measuredbefore and after the interven-tion .[Result] The body weight ,BMI and waist circumstancewere significantly decreased in the both groups ,butshowed more significantdecreasein the VLCD intervention group ( P< 0.01 ) .There were no significant difference in bone turnover between the two groups after intervention (P>0.05) .[Conclusion]Short-term very low carbohydrate diet intervention can improve body weight ,BMI and waist circumstance in overweight or obese subjects while has no significant impact on bone turnover .
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