CRRT对重症急性胰腺炎患者脂联素 TNF-α和CRP的影响

摘要

目的探讨重症急性胰腺炎(SAP)患者脂联素、TNF-α和CRP水平的变化特点及连续性肾脏替代疗法(CRRT)对其影响.方法按照平行对照设计原理，将所有66例患者分为对照组和CRRT组.对两组患者的相关临床资料及脂联素、TNF-α和CRP水平进行比较.结果与CRRT组患者比较，对照组患者第1天TNF-α和CRP水平均明显升高(均P<0.05)，脂联素水平明显降低(P<0.05)；与CRRT组患者比较，对照组患者第2、3天TNF-α和CRP水平均明显升高(均P<0.01)，脂联素水平明显降低(均P<0.01)；治疗前两组患者脂联素、TNF-α和CRP水平，差异无统计学意义(均P>0.05)；在年龄、性别、APACHE II评分等方面两组差异无统计学意义(均P>0.05).结论 CRRT能通过降低TNF-α和CRP水平及升高脂联素水平，对SAP患者起到较好的治疗作用.%　　Objective To explore the changes of adiponectin,tumor necrosis factor-α,C-reactive protein as well as the effects of CRRT in patients with severe acute pancreatitis(SAP). Methods 66 patients with SAP Were collected.The patients were divided into control group and CRRT treatment group,the characters of clinical and the Level of adiponectin, tumor necrosis factor-α,C-reactive protein were compared between the two groups. Results the lever of tumor necrosis factor-α、C-reactive protein were significantly higher in control group group than that in CRRT treatment group in day 1 (bothP<0.05),the lever of adiponectin was significantly lower in control group group than that in CRRT treatment group in day 1(bothP<0.05);the lever of tumor necrosis factor-α、C-reactive protein were significantly higher in control group group than that in CRRT treatment group in day 2 and day 3(allP<0.01),the lever of adiponectin were significantly lower in control group group than that in CRRT treatment group in day 2 and day 3(bothP<0.01);there is no significant differences between control group and CRRT treatment group in adiponectin、tumor necrosis factor-α、C-reactive protein before treatment(all P>0.05);there is no significant differences between control group and CRRT treatment group in Age、gender、APACHE II score (all P>0.05). Conclusion CRRT can effectively reduce the plasma levels of TNF-α、CRP and Increase the plasma levels of adiponectin in SAP patients,it play a therapeutic effect through changing the cytokine of SAP patients.