子痫前期并发胎盘早剥的相关因素研究

摘要

目的：探讨子痫前期并发胎盘早剥的相关因素。方法子痫前期患者78例，根据是否发生胎盘早剥分为观察组（子痫前期合并胎盘早剥组）18例、对照组（子痫前期未合并胎盘早剥组）60例，调查两组产妇年龄、体质指数（BMI）、孕产次、孕周、分娩次数、流产次数、血压情况，采集血清检测血肌酐（cr）、尿素氮（BUN）、纤维蛋白原（FIB）、内皮素1（ET-1）、一氧化氮（NO）的含量。结果观察组患者分娩次数、流产次数多于对照组，cr、BUN、ET-1含量明显高于对照组，FIB、NO含量明显低于对照组（P<0.05）；分娩次数和流产次数多以及cr、BUN、ET-1含量高是子痫前期并发胎盘早剥的危险因素（ P<0.05），FIB含量和NO含量高是子痫前期并发胎盘早剥的保护因素（P<0.05）。结论分娩次数和流产次数多以及肌酐、尿素氮、ET-1含量高的产妇发生子痫前期并发胎盘早剥的风险较高，纤维蛋白原含量和NO含量高的产妇发生子痫前期并发胎盘早剥的风险较低。%Objective To study the related factors of preeclampsia complicated by placental abruption. Methods 78 cases patients with preeclampsia from September 2013 to December 2014 in our hospital were divided into observation group (preeclampsia complicated by placental abruption) 18 cases and control group(preeclampsia group no complicated by placental abruption) 60 cases. Then age,BMI,maternal time, gestational age,birth numbers and abortion numbers,blood pressure were collected,cr,BUN,FIB,ET-1),NO content were detected. Results Birth numbers and abortion numbers of observation group were higher than the control group,cr,BUN,ET-1 levels were higher than the control group,FIB and NO contents were lower than the control group(t=7.987~24.852,P<0.05); more birth numbers and abortion numbers, high cr,BUN,ET-1 contents were risk factors for preeclampsia complicated by placental abruption(P<0.05); high levels of FIB and NO contents were protective factors for preeclampsia complicated by placental abruption(P<0.05). Conclusion Risk of preeclampsia complicated by placental abruption is higher in maternal with more birth numbers and abortion numbers and high creatinine,urea nitrogen,ET-1 contents are higher;while the risk is lower with high levels of fibrinogen and NO contents.