血清PCT CRP LPS检测对SAP后期感染性胰腺坏死的诊断价值

摘要

Objective To investigate the diagnostic value of serum inflammatory index for infected pancreatic necrosis in the late course of severe acute pancreatitis. Methods The clinical data of 450 patients treated in our hospital from August 2012 to August 2016 were collected,and the patients were divided into infection group and non-infection group. The blood detection indexes and ROC curve analysis results of the two groups were compared. Results The incidence of infectious pancreatic necrosis was 21.8%. The area under the ROC curve of PCT,CRP,LPS and lipase were 0.903,0.884,0.882 and 0.580,the cut-off value were 7.0μg/L,229.0 mg/L,3.5 EU/ml and 592U/L,the sensitivity were 89.6%,87.5%,87.2%and 65.9%,the specificity were 83.6%,81.4%,80.9% and 58.7%,respectively. Conclusion Serum PCT,CRP and LPS have major diagnostic value for infected pancreatic necrosis in the late course of SAP.%目的 探讨血液炎性指标对重症急性胰腺炎(SAP)发生后期感染性胰腺坏死的诊断价值.方法 收集2012年8月至2016年8月诊治的450例SAP患者临床资料,分为坏死组和非坏死组,比较两组患者各项血液检测指标及ROC曲线分析结果.结果 感染性胰腺坏死发生率为21.8%.坏死组患者血清PCT、CRP、LPS及脂肪酶含量明显高于非坏死组患者(P<0.05).坏死组患者与非坏死组患者血淀粉酶、白细胞计数、血红蛋白、白蛋白比较差异无统计学意义(P>0.05).ROC曲线分析结果显示PCT、CRP、LPS及脂肪酶对应曲线下面积分别为0.903、0.884、0.882、0.580,诊断临界值分别为7.0μg/L、229.0mg/L、3.5kEU/L、592U/L,敏感度分别为89.6%、87.5%、87.2%、65.9%,特异度分别为83.6%、81.4%、80.9%、58.7%.结论 血清PCT、CRP、LPS检测对SAP发生感染性胰腺坏死具有一定的诊断价值.