原发性干燥综合征患者听力学特点分析

摘要

目的：分析原发性干燥综合征（pSS）患者的听力学特点及其听觉损害特征。方法对71例pSS患者进行纯音听阈测定、声导抗、听觉脑干诱发电位检查，与健康对照组63例进行比较。并对听力减退的pSS患者分别进行病程与双耳平均听阈值、年龄与双耳平均听阈值的相关性分析。结果71例pSS患者听力减退25例（41耳），患病率28.9%，63例健康对照组检出听力减退16例（23耳），患病率为18.3%， pSS患者听力减退患病率高于对照组，差异有统计学意义（χ2=4.142，P<0.05）。在语言频率，pSS患者的双侧纯音测听指标与健康对照组差异无统计学意义（P>0.05）；而在4kHZ和8kHZ，pSS患者均明显高于健康对照组（P<0.05）；pSS患者的声导抗图以A型图为主，两组对象的鼓室导抗图比较差异无统计学意义（P>0.05）。BAEP检查结果表明，pSS患者在Ⅰ~Ⅴ的IPL明显延长，高于健康对照组（P<0.05）。25例听力减退的pSS患者病程与听阈值显著相关（r=0.403，P<0.05），年龄与听阈值无显著相关（r=0.301，P>0.05）。结论 pSS患者的听力损害可能是内耳系统的病变，对这一群体应注意监测听力。%ObjectiveTo evaluate the characteristics of hearing loss in patients with primary Sjögren's syndrome(pSS). Method Acomparative case-control study was performed with 71patients and 63 healthy subjects. All of them were submitted to pure-tone audiometry and tympanogram and BAEP.ResultsHearing loss was detected in 28.9% of patients performed with pSS(18.3% in controls;P<0.05),emerged at the high frequencies. It was found that only a few cases presented unnormal tympanograms. The IPL ofⅠ~Ⅴ in the BAEP was prolonged. A correlation between hearing level and the duration of the disease was found,while there was no correlation with age.ConclusionsHearing loss with pSS is located in the inner ear.Audiological evaluation must be performed periodically to identify possible audiological damage.