（1R,2S）-2-（3,4-二氟苯基）环丙胺扁桃酸盐的合成

摘要

以邻二氟苯为原料，经傅克酰化、缩合、还原、环合，最后与D-扁桃酸成盐制得替卡格雷关键中间体(1R,2S）-2-(3,4-二氟苯基）环丙胺扁桃酸盐，总收率32.6%，ee值99.8%。%(1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamine mandelate,the key intermediate of ticagrelor, was synthesized form 1,2-difluorobenzene via Friedel-Crafts acylation,condensation, recovery, cyclization with a yield of 32.6%. The ee value of the target compound was 99.8%.