Objective To assess the release of angiogenin into peritoneal fluid i n women w ith and without endometriosis by measuring its concentration with reference to d isease stage, presence of red lesions, and phase of the menstrual cycle. Design Retrospective study. Setting Nagoya City University Hospital. Patient(s) Sixty- four women with endometriosis (n = 38) and cystadenomas (n = 26) for whom surger y was scheduled in the proliferative or secretory phase of the menstrual cycle. Intervention(s) Peritoneal fluid samples were obtained at laparotomy or laparosc opy. Main outcome measure(s) Angiogenin concentrations in the peritoneal fluid, as measured by ELISA. Result(s) Angiogenin concentration in the peritoneal fluid was markedly elevated in the endometriosis patients (median 515 ng/mL, interqua rtile range 151-1763 ng/mL) comparedwith the cystadenoma (control) patients (195 ng/mL, 98-324 ng/mL)-, with values corre lating with the extent of the disease. No significant differences between the pr oliferative phase and the secretory phasewere observed in either the controls or the endometriosis patients. Conclusion(s) The inflammation associated with endo metriosis, through increasing levels of peritoneal fluid angiogenin, might promo te angiogenesis for progression of the disease and correlate with the extent of the disorder.
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