CORRELATION OF RATIO OF TP TO DPDmRNA EXPRESSION LEVEL IN COLORECTAL CANCER WITH DISEASE-FREE SURVIVAL RATIO IN 5-FU TREATED PATIENT

摘要

PPROBLEM TO BE SOLVED: To provide a method for identifying a parameter indicative for susceptibility to 5-fluoro-uracil (5-FU) and/or a 5-FU analogue in all potential parameters suggested in the prior art, and for determining under what conditions the parameter provides the highest possible specificity. PSOLUTION: The method for determining whether a patient suffering from cancer is susceptible to a treatment with the 5-FU and/or the 5-FU analogue comprises (a) determination of tymidine phosphorylase (TP) mRA expression in a clinical sample, (b) determination of diphydropyrimidine dehydrogenase (DPD) mRNA expression in the clinical sample, (c) determination of the ratio of the value obtained in step (a) to the value obtained in step (b), and (d) whether the ratio obtained in step (c) exceeds a predetermined cut off value. PCOPYRIGHT: (C)2005,JPO&NCIPI