目的：探讨子宫内膜异位（EMT）患者腹腔液中瘦素及白介素－8（IL －8）的表达差异及其与 EMT 进展的相关关系。方法：选取53例 EMT 患者（EMT 组）及45例对照组患者，采集其腹腔液并通过酶联免疫吸附法（ELISA）对瘦素及 IL －8表达水平进行测定，分析两组患者表达水平差异及其与 EMT 患者rAFS 分期、疼痛评分的相关性。结果：EMT 组患者相较对照组患者出现瘦素及 IL －8表达水平的升高，并且差异具有统计学意义（均 P ＜0．001）。早期 EMT 患者瘦素表达水平相较晚期 EMT 组明显升高（P ＜0．001），而 IL －8表达水平则明显降低（P ＜0．001）。卵巢巧克力囊肿组患者瘦素表达水平明显低于盆腔EMT 组（4．8±1．7ng／L vs．9．3±2．5ng／L，P ＜0．001），但两组患者腹腔液 IL －8表达水平差异则不具有统计学意义（P ＝0．651）。Pearson 相关分析表明，瘦素表达水平与患者 rAFS 呈现负相关关系（r ＝－0．5731，P ＜0．05）而与 EMT 患者疼痛评分不具有相关关系（r ＝0．0036，P ＞0．05）。IL －8表达水平与患者 rAFS 呈现正相关关系（r ＝0．6148，P ＜0．05）而与晚期 EMT 患者的疼痛评分具有显著的正相关关系（r ＝0．6391，P ＜0．05）。结论：EMT 患者腹腔液出现瘦素及 IL －8的异常增高并且其与 EMT 的进展及临床症状具有一定相关性，值得在临床上对其进行关注。%Objectives:To explore the expression difference of leptin and interleukin -8 (IL -8)in peri-toneal fluid and their correlation with the progression of endometriosis (EMT).Methods:53 patients with EMT (EMT group)and 45 otherwise patients were selected and the peritoneal fluid was collected to detect the expression level of leptin and IL -8 using the ELISA.The expression level of leptin and IL -8 were compared between the two groups and their correlation with rAFS stage and pain scores were analyzed.Results:Level of leptin and IL -8 in EMT group increased compared with the control group (P <0.001 ).Significantly higher level of leptin and lower level of IL -8 were demonstrated in patients of EMT early stage than that of advanced stage (both P <0.001 ).Lev-el of leptin in patients with single chocolate cyst of ovary significantly decreased (4.8 ±1 .7ng/L vs.9.3 ±2.5ng/L,P <0.001 )compared with those with single pelvic EMT,but difference in the IL -8 expression is not statistical-ly significant (P =0.651 ).Pearson correlation analysis showed that expression level of leptin correlated negatively with rAFS stage of patients (r =-0.5731 ,P <0.05)and not correlated with patients’pain scores (r =0.0036,P>0.05).Expression level of IL -8 correlated positively with rAFS stage of patients with EMT (r =0.61 48,P <0.05)and with pain scores in patients with advanced EMT (r =0.6391 ,P <0.05).Conclusion:Expression lev-els of leptin and IL -8 increase in peritoneal fluid in patients with EMT and correlates with the progression of EMT and clinical symptoms,which is worth more attention in clinical practice.
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