ABSTRACT:Objective To observe the efficacy and adverse reactions of norfloxacin eye drops and gatifloxacin eye drops in the treatment of acute bacterial conjunctivitis. Methods 86 patients with acute bacterial conjunctivitis who were treated in our hospital during December 2013 to December 2014 were taken as the research objects. According to the random number table method, the patients were divided into the control group (43 cases) and the observation group (43 cases). The control group used norfloxacin eye drops for treatment while the observation group used gatifloxacin eye drops for treatment. The therapeutic effect of the two groups was observed and the occurrence of adverse reactions was recorded. Results The total effective rate of the control group and the observation group were 88.4%and 83.7%respectively. The difference between the two groups was not statistically significant (P>0.05). Compared with the control group, the incidence of adverse reactions in the observation group was 14% which was lower and the difference between the two groups was statistically significant (P<0.05). Conclusion Norfloxacin eye drops and gatifloxacin eye drops in the treatment of acute bacterial conjunctivitis can obtain good effect. Gatifloxacin eye drops is with less adverse reactions, which is more suitable for clinical promotion.%目的：观察诺氟沙星滴眼液与加替沙星滴眼液治疗急性细菌性结膜炎的疗效及不良反应。方法研究对象源自于我院2013年12月至2014年12月收治的86例急性细菌性结膜炎患者，按随机数字表法分为对照组（43例）与观察组（43例）。对照组使用诺氟沙星滴眼液治疗；观察组使用加替沙星滴眼液治疗。观察两组治疗效果，记录不良反应发生情况。结果对照组与观察组治疗总有效率分别为88.4%和83.7%，两组比较差异无统计学意义（P>0.05）；较对照组，观察组不良反应发生率14.0%低，两组比较差异有统计学意义（P<0.05）。结论诺氟沙星滴眼液与加替沙星滴眼液治疗急性细菌性结膜炎均能获得良好效果，加替沙星滴眼液不良反应少，更适合于临床推广。
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