联合检测血清CEA与CA724在结直肠癌中的临床意义研究

摘要

Objective concentration detection of colorectal cancer CEA and CA724 serum tumor markers and their clinical significance.Methods 96 cases of hospitalized patients with colorectal cancer in our hospital, to the study group, in accordance with different clinical stages of the study were divided into two groups (Ⅰ-Ⅱ) of the group (35 cases),Ⅲ stage group (30 cases ),Ⅳ stage group (31 cases), alternatively the same period in our hospital 30 cases of colorectal polyps in patients with proctitis, as control group, chemiluminescence detection of electricity in all patients CEA, CA724 concentration and statistical analysis .Results The study group of patients with CEA, CA724 concentration was higher (P<0.05);Ⅳ stage patients of CEA, CA724 concentrations above (Ⅰ-Ⅱ) group andⅢ stage of group (P<0.05),Ⅲ period group of patients with CEA, CA724 concentrations above (Ⅰ-Ⅱ) stage group (P<0.05); compared with the separate detection, combined detection sensitivity (86.3%), in line with the rate of (88.6%), Youden index (0.75 ), negative predictive value (78.6%) were increased to varying degrees.Conclusion The combined detection of CEA and CA724 helps early diagnosis of colorectal cancer and the severity of the evaluation, may be considered application.%目的：检测结直肠癌血清肿瘤标记物CEA与CA724的浓度并分析其临床意义。方法选取本院收治的96例结直肠癌住院患者，设为研究组，依据临床分期的不同，将研究组患者分为（Ⅰ-Ⅱ）期组（35例）、Ⅲ期组（30例）、Ⅳ期组（31例），另选同期于本院就诊的30例结直肠炎性息肉患者，设为对照组，用电化学发光法检测所有患者CEA、CA724的浓度并进行统计学分析。结果研究组患者的CEA、CA724浓度高于对照组（P<0.05）；Ⅳ期组患者的CEA、CA724浓度高于（Ⅰ-Ⅱ）期组及Ⅲ期组（P<0.05），Ⅲ期组患者的CEA、CA724浓度高于（Ⅰ-Ⅱ）期组（P<0.05）；与单独检测相比，联合检测的灵敏性（86.3%）、符合率（88.6%）、约登指数（0.75）、阴性预测值（78.6%）均不同程度提高。结论联合检测CEA与CA724有助于结直肠癌的早期诊断及严重程度评价，可考虑推广应用。