通腑化瘀导痰汤对重型颅脑损伤血清S-100β、NSE及预后的影响

摘要

Objective:To research effect of Tongfu Huayu Daotan tang on S-100β(serum protein)、neuron specific enolase (NSE) of serious head injury, and discuss disease' progress under influence of Chinese medicine.Methods:Sixty patients were randomly grouped to control group, subject to western comprehensive treatments, and treat group given the medicine in addition. S-100β、NSE tests were taken on 1st day of admission, (after treatment)24h, 36h, 72h, day5, day7 respectively. Effectiveness was evaluated according to Glasgow Outcome Scale and Neurologic Impairment Score in 2,4 weeks following injury occurrence. Results:At time points of 1st day, 24h, 36h, there wasn't statistic difference between groups (P>0.05); at 72h, day5, day7, the treat group was significantly reduced in S-100βand NSE (P<0.01), and higher evaluated (P<0.05) compared with those of the control group.Conclusion:As a supplement to western comprehensive treatments, Tongfu Huayu Daotan tang is positive for serious head injury as shown by higher scale of GOS and score of neurologic impairment.%目的:探讨通腑化瘀导痰汤对重型颅脑损伤血清S-100β蛋白及血清神经元特异性烯醇化酶(NSE)浓度变化及预后的影响.方法:将60例重型颅脑损伤患者随机分为对照组和治疗组,对照组采用西医综合治疗,治疗组予通腑化瘀导痰汤加西医综合治疗.对2组患者,分别于入院时,治疗后24h、36h、72h、5天及7天抽血进行血清S-100β蛋白及血清神经元特异性烯醇化酶(NSE)浓度检测,并于伤后第2周及第4周用GOS预后分级方法及神经功能缺损评分评定临床疗效,并将所得数据进行统计学分析.结果:入院时、治疗后24h及36h 2组血清NSE、S-100β蛋白含量无显著性差异(P>0.05);治疗后72h、5天、7天,治疗组血清NSE、S-100β蛋白含量明显降低(P<0.01);治疗后治疗组GOS预后分级评分及神经功能缺损评分明显优于对照组(P<0.05).结论:在西医综合治疗同时使用中药通腑化瘀导痰汤可以提高重型颅脑损伤GOS预后分级和神经功能缺损评分,对治疗重型颅脑损伤有一定的作用.