消渴丸对GK大鼠心、肾影响的研究

摘要

Objective:To compare the impact on GK ratsheart and kidney by TCM component of Xiaoke Wan,the chemical component (Glibenclamide)of Xiaoke Wan and Xiaoke Wan,in order to explore the role of the TCMcomponent in Xiaoke Wan.Methods:After 24 weeks respective administration of the traditional component of Xiaoke Wan,the chemical component of Xiaoke Wan and Xiaoke Wan,the GK rats were sacrificed,and a series of index were measured such as the microstructure of the heart and kidney,the subcellular structure of the heart and kidney.Results:The microstructure of the heart and kidney,and the subcellular structure of heart and kidney were amel-iorated by the TCM component of Xiaoke Wan and Xiaoke Wan,and the effect was dose-dependent.Conclusion:In this study,the TCM component of Xiaoke Wan plays an important role of reducing the heart and kidney complication of diabetes mellitus,the mechanism of which needs further research.%目的：通过比较消渴丸中药组分与消渴丸、消渴丸化药组分（格列本脲）对GK大鼠心、肾的影响，探索消渴丸中药组分在消渴丸中的作用。方法：消渴丸中药组分、消渴丸、格列本脲连续给药24周后观察心脏、肾脏的组织形态学变化以及超微结构变化。结果：消渴丸中药组分、消渴丸均能够明显改善GK大鼠心脏和肾脏的组织形态学以及超微结构，并具有一定的量效关系。结论：消渴丸中药组分在消渴丸处方中的作用可能与预防糖尿病心肾并发症的发生有关，值得进一步研究。