丹红注射液对下肢骨折患者凝血及局部微循环状态的影响研究

摘要

目的：探讨丹红注射液对下肢骨折患者凝血功能和局部微循环状态的影响。方法：将2012年9月至2013年2月期间本院收诊的下肢骨折患者随机分成2组，对照组和治疗组各72例。所有患者均采用手术内固定治疗骨折，治疗组患者术后静脉滴注丹红注射液，40 mL（次·d），连续给药2周。比较治疗前后2组患者间骨代谢指标、凝血功能指标及微循环相关指标差异。结果：治疗7、28 d后，治疗组骨碱性磷酸酶（Bone Alkaline Phosphatase，BALP）比例和血清碱性磷酸酶（Alkaline Phospha-tase，BGP）、I型前胶原羧基端肽（Procollagen Carboxyl Terminal Peptide，PICP）浓度显著高于对照组，内皮素（Endothelin，ET）和血清C反应蛋白（C Reactive Protein，CRP）水平显著低于对照组；治疗组患者凝血酶时间（Thrombin Time，TT）、凝血酶原时间（Pro-thrombin Time，PT）、活化部分凝血活酶时间（Activated Partial Thromboplastin Time，APTT）、纤维蛋白原（Fibrinogen，Fb）显著长于对照组；治疗组患者甲襞微循环指标形态积分、流态积分、周围状态积分和总积分显著低于对照组，毛细血管流速显著快于对照组，而白微栓则显著低于对照组（P＜0.05）。结论：丹红注射液有助于下肢骨折患者凝血功能和微循环障碍的改善，有利于患者的骨骼愈合。%Objective:To observe the influence of Danhong injection on the coagulation and local microcirculation of patients with lower extremity fractures.Methods:Patients with lower extremity fractures treated in our hospital from September 2012 to February 2013 were randomly divided into control group (n=72)and observation group (n=72).All the patients were treated with internal fixation treat-ment,and patients in observation group were also treated with danhong injection,40ml/time/day,for 2 weeks.Then the indexes of bone metabolism,coagulation and local microcirculation of two groups were compared.Results:After 7,28 days of treatment,the serum levels of BALP,BGP and PICP of observation group were all higher than those of the control group;the ET and CRP were lower than those of control group;and the TT,PT,APTT,Fb of observation group were significantly shorter than those of the control group;the indexes of nailfold microcirculation such as form integral,flow state integral,points around the state and total integral of observation group were all significantly lower than those of the control group;the capillary flow rate was much faster in observation group;white micro-bolt of the observation group was lower than that of control group,all P<0.05 .Conclusion:Danhong injection can effectively improve the coagula-tion and local microcirculation of patients with lower extremity fractures,and benefit the patients bone healing.