Microcirculatory Behavior under the Influence of Electromagnetic and Corpuscular Radiations for the Purpose of Understanding the Mechanism of Intravasal Clotting

摘要

Data, collected over a period of years and indicating that in the frog UV induced stasis results from a disturbance of the steady state between intravasal clotting and fibrinolysis, were analysed statistically in regard to the striking seasonal variation shown by the physiological responses of the frog. This variation was taken into account in comparing experimental results obtained at different times of the year. This analysis as well as the analysis of the normal physiological variations of hemodynamics and clotting potential revealed a strong correlation between these two parameters and suggested that the onset of disseminated intravascular coagulation requires a slowed-down perfusion together with an increased clotting potential. To expand these studies to mammals, reflected light microscopy is combined with ectronic methods for the continuous quantitative recording of the main parameters of capillary circulation in intact accessible mammalian tissues. Three different methods are currently under investigation for obtaining such continuous recordings: (1) from the video signal itself, (2) photoelectrically from the image on the screen, and (3) using analog autocorrelaton systems. (Author)