平糖舒目散治疗糖尿病的作用机制初探

摘要

目的：通过醛糖还原酶高通量模型对中药方剂平糖舒目散的筛选，探寻其治疗糖尿病的作用机制。方法：用高通量醛糖还原酶筛模型来筛选平糖舒目散，研究方剂平糖舒目散对醛糖还原酶的抑制作用。结果：平糖舒目散对醛糖还原酶有较强的抑制作用，其半数抑制浓度是0.8g／L。结论：中药方剂平糖舒目散治疗糖尿病慢性并发症的作用机制之一是抑制醛糖还原酶活性。%Objective:To explore the mechanism of Chinese prescription Pingtang Shumu powder in treating diabetes by screening it in high-flux aldose reductase models.Methods:High-flux aldose reductase model was used to screen Pingtang Shumu powder,so as to study on its exhibition effect on aldose reductase.Results:Pingtang Shumu powder had strong exhibition effect on aldose re-ductase with the Icso of 0.8g/L.Conclusion:The mechanism of Chinese prescription of Pingtang Shumu powder treating chronic complications of diabetes is to exhibit the activity of aldose reductase.