DM超乳术后患者应用芪明颗粒联合妥布霉素地塞米松、普拉洛芬滴眼液在预防术后黄斑中心凹厚度增加中的作用

摘要

Objective:To investigate the application of Qi Ming granule combined with tobramycin and dexamethasone,Pranoprofen Eye Drops in DM phaco patients increasing foveal thickness in the prevention of postoperative.Methods:All 98 cases (98 eyes) with diabetes who needed white in ultrasonic emulsification surgery were selected in our hospital from May 2014 to May 2014 according to random number table method.They were all randomly divided into two groups,a control group and a research group,in which the control group received tobramycin dexamethasone eye drops for treatment after surgery,while the research group patients taking extra Pranoprofen Eye Drops,comparing the two groups' ocular findings and concave macular center thickness before and after treatment.Results:Two groups of patients' postoperative BCVA significantly were higher than before (P ＜ 0.01);and 1 months after surgery and 3 months after operation in the research group,BCVA was significantly higher than that of the control group (P ＜ 0.05).The foveal thickness in the two groups after operation were significantly higher than that of preoperative (P ＜ 0.01);and 3 months after operation test of the foveal thickness were (166.88 ± 15.90) m,significantly lower than that of the control group (173.15 ± 16.60) m (P ＜ 0.05).There were 3 cases (6.12％) patients with macular edema in the research group,while 3 patients (18.37％) in the control group had macular edema after 9 months of operation.Conclusion:In phacoemulsification after the combined application of tobramycin and dexamethasone in patients with diabetes mellitus and Qiming granules and Pranoprofen Eye Drops,the incidence of postoperative macular edema was significantly reduced,and the postoperative increase of foveal thickness was effectively prevented.%目的:探讨DM超乳术后患者应用芪明颗粒联合妥布霉素地塞米松、普拉洛芬滴眼液在预防术后黄斑中心凹厚度增加中的作用.方法:选取2014年5月至2016年5月河北省人民医院眼科收治需要进行白内超声乳化手术的糖尿病患者的98例(98眼),并按照随机数字表法将所有患者随机分为对照组和观察组,其中对照组患者在术后采取妥布霉素地塞米松滴眼液进行治疗,而观察组患者则采取芪明颗粒联合妥布霉素地塞米松、普拉洛芬滴眼液进行治疗,观察比较2组患者治疗前后的眼部检查结果以及黄斑中心凹厚度.结果:2组患者术后的BCVA情况显著均高于术前(均P＜0.01),而术后1个月以及术后3个月时观察组患者的BCVA均显著高于对照组患者(均P＜0.05).2组患者术后的黄斑中心凹厚度均显著高于术前(均P ＜0.01),并且术后3个月时观察组患者的黄斑中心凹厚度为(166.88±15.90) μm显著低于对照组患者的(173.15±16.60) μm(P ＜0.05).观察组中有3例(6.12％)患者出现黄斑水肿,而对照组患者在术后3个月时有9例(18.37％)患者出现黄斑水肿.结论:在超声乳化手术后对糖尿病患者联合应用妥布霉素地塞米松和芪明颗粒、普拉洛芬滴眼液,能够显著减少患者术后黄斑水肿的发生率,并且有效防止患者术后出现黄斑中心凹厚度的增加.