复方玉屏风散对小鼠细胞免疫力的增强作用研究

摘要

Objective: To compare the differences between compound YuPingFengSan oral liquid and FuQi ZhiHan granules in improving cellular immunity of mice with immunosuppression. Method: The models of immunosuppression mice were made through peritoneal injection of cyclophosphamide and then received gastric administration of physiological saline, YuPingFengSan oral liquid[6 g/(kg·d)] and FuQi ZhiHan granules[27 g/(kg·d]. Thymus and spleen index, proliferation index of T-lymphocyte, sub T-lymphocyte, the level of INF-γ and phagocytic indexes of peritoneal macrophages were tested. Result: Both of the drugs could improve thymus and spleen index, proliferation index of T-lymphocyte, lymphocytic percentages of CD3+, CD4+and CD8+as well as the level of serum INF-γ, the difference between both drugs had statistical meaning (P<0.05). Conclusion:YuPingFengSan oral liquid and FuQi ZhiHan granules could improve cellular immunity of mice with immunosuppression, but clinical efficacy of YuPingSan oral liquid is better than FuQi ZhiHan granules.%目的：比较复方玉屏风散口服液和复芪止汗颗粒在提高免疫抑制小鼠细胞免疫功能方面的差异。方法：小鼠腹腔注射环磷酰胺制备免疫抑制模型，分别以生理盐水、玉屏风散口服液(6 g/kg·d)和复芪止汗颗粒(27 g/kg·d)灌胃，测定其胸腺和脾脏指数、T淋巴细胞增殖指数，T淋巴细胞亚群、INF-γ水平及腹腔巨噬细胞吞噬指数。结果：玉屏风散口服液和复芪止汗颗粒均能提高免疫抑制模型小鼠的胸腺和脾脏指数、T淋巴细胞增殖指数，CD3+、CD4+和CD8+淋巴细胞百分比及血清INF-γ水平，但两者之间比较差异具有统计学意义(P＜0.05)。结论：玉屏风散口服液和复芪止汗颗粒均能提高免疫抑制小鼠的细胞免疫功能，但玉屏风散口服液效果优于复芪止汗颗粒。