Macrophage plays an important role in human innate immune system. It has powerful functions, such as recog-nition, phagocytosis, and bacteria and foreign body removal. Periodontitis, which is a chronic infectious disease characterized by gum inflammation and bone loss, is a major cause of tooth loss in adults. Several studies demonstrated that periodontal tissue destruction is caused by the host immune response defending against infections. As an important part of host immune response, macrophage is also involved in periodontitis pathogenesis. Recently, anti-inflammatory and proresolving activities of macrophage was discovered. Thus, the complex function of macrophage in the occurrence, development, and resolution of inflammation and its potential role in periodontitis were reviewed.%巨噬细胞是人体固有免疫系统中重要的组成部分,具有强大的识别、吞噬、清除细菌及外来异物的功能.牙周炎是一种以牙龈炎症和牙槽骨丧失为特征的慢性感染性疾病,是成年人失牙的主要病因.目前已经明确,牙周炎的组织破坏是由宿主对感染的免疫应答引起的,巨噬细胞作为宿主免疫应答的重要组成部分,在炎症的发生发展中起重要作用.近年研究显示,巨噬细胞在炎症消退过程中亦扮演着重要作用.本文就巨噬细胞在炎症的发生、发展及消退中的作用进行综述,并总结了其在牙周炎发展及治疗中可能的作用.
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