琥珀酸美托洛尔缓释片在高龄合并快速永久性心房颤动治疗中的有效性和安全性分析

摘要

Objective To analysis of effectiveness and security of metoprolol succinate sus-tained-release tablets in treating the elder patients of permanent atrial fibrillation with fast ventricular rate .Methods Forty elder patients of permanent atrial fibrillation with fast ventricular rate were en-rolled in the trial , they were given small dose metoprolol tartuate tablet orally and gruadually in-creased dosage for 2 weeks.Then replaced by metoprolol succinate sustained-release tablets with ratio of 1∶1 and observed for 2 weeks.The patients symptom, 24 h mean heart rate, morning resting heart rate, mean blood pressure, and brain natriuretic peptide (BNP) individually recorded and analyzed . Results The average of target dose of metoprolol was ( 66.25 ±18.75 ) mg.Metoprolol succinate sustained-release tablets could improve patients symptom , 24 h mean heart rate , morning resting heart rate , mean blood pressure and BNP ( P<0.05 ) .By analysis with the holter , there were not found more longer R-R intervals when rearch the tartuate tablet (P>0.05).Conclusion In treating the elder patients with permanent atrial fibrillation with fast ventricular rate , metoprolol succinate sustained-release tablets are effectiveness and security , and worth to use in clinic .%目的：分析琥珀酸美托洛尔缓释片在高龄合并快速永久性心房颤动治疗中的有效性和安全性。方法选取70岁以上伴有快速永久性心房颤动40例。在基础治疗上加用小剂量酒石酸美托洛尔片逐渐达到靶剂量，2周后按照1∶1更换为琥珀酸美托洛尔缓释片，继续观察2周。分别记录患者症状、清晨静息心率，检查B型尿钠肽、动态心电图及动态血压并进行分析。结果琥珀酸美托洛尔缓释片的治疗靶剂量为（66.25±18.75） mg。患者在琥珀酸美托洛尔缓释片治疗后症状、24 h平均心率、清晨静息心率、24 h平均血压、B型尿钠肽均较用药前明显改善，差异有统计学意义（ P＜0.05）。琥珀酸美托洛尔缓释片当使用到靶剂量时最长R-R间期无明显延长，患者未出现不适症状。结论在高龄合并快速永久性心房颤动治疗中，琥珀酸美托洛尔缓释片有着良好的临床疗效和安全性，值得临床应用。