无线光刺激与神经传感系统

摘要

Neuromodulation based on optogenetics is developed toward closed-loop control,a wireless light stimulation and neural sensing system is developed for requirements of free moving of test animal which has functions of larger range of optical stimulation,synchronous record,wireless programmable,which contains light stimulation-electric record neural interface,a stimulating and sensing module,a wireless transceiver module and upper PC software. The device can adjust light stimulation frequency,amplitude,duty ratio wirelessly and in real-time and synchronously acquire neural signal. The animal experiment shows that 30 Hz light stimulation at motor cortex movement of the mice is obviously enhanced,and EEG signal provoked by stimulation is recorded simultaneously. The system provides a multifunction neural regulation platform for optogenetics,which is beneficial to long schedule research for neural circuit and neural disease.%光遗传神经调控正在向闭环技术发展，针对实验动物可自由活动的需求，研发具有大范围光刺激、神经信号同步记录、无线程控等功能的无线光刺激与神经传感系统。该系统包括光刺激—电记录神经接口、刺激传感模块、无线收发模块以及上位机软件。可无线实时调节光刺激频率、幅度和占空比等参数，并同步采集神经信号。给予小鼠刺激运动皮层30Hz光刺激，小鼠运动明显增强，同时记录到刺激诱发的脑电信号。系统为光遗传技术提供多功能神经调控平台，有助于神经环路和神经疾病的长时程研究。