Background:Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease,and with few major advances in therapy methods over the last years.It's hard to verify the pathogenesis of AIH and effective novel treatments for AIH because of lacking proper animal models,nor to accurately reproduce the human condition.To find clues to overcoming the therapeutic insufficiency,preclinical animal models are needed.Concanavalin A-mediated AIH model has been widely used in the experiences.Generally,serum ALT levels were tested to assess the animal models.The purpose of this study is to reveal the correlation between ALT serum levels in ConA-induced AIH mouse models and ConA dose and duration.Methods:Animal studies in eight databases(PubMed,Cochrane's library,Excerpta Medica Database(Embase),Web of Science,China National Knowledge Internet(CNKI),Wan fang database,Weipu Data-base(VIP)and China Biomedical Literature Database(CBM))were searched up to May 2020.This study performed a meta-analysis by comparing the ALT serum level in the AIH animal models.We did register our research in PROSPERO.(https://www.crd.york.ac.uk/PROSPERO/)The ID is CRD42020182967.Result:11 studies with 265 mice were included in our meta-analysis.The serum level of ALT of the AIH model animals(mean difference(MD)4.83,P<0.001)was higher than that of the control group.Conclusion:This study found that ALT levels could be elevated after caudal vein injection of ConA.Different time points also affect ALT serum levels.More experiences studies are need to further illustrate the effect of Con-A administration in experimental models.
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