Objective To investigate the effect of cholesteryl ester transfer protein (CETP) on lipid parameters in patients with coronary heart disease (CHD). Methods Five hundred and fifty-five cases were divided into CHD group (n= 430) and control group (n=120) according to the result of coronary angiography (CAG). The plasma levels of CETP, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1(ApoA1), apolipoprotein B (ApoB) and ApoA1/ApoB were measured and analyzed respectively in two groups. Results The values of HDL-C, ApoA1 and ApoAl/ApoB were significantly lower in CHD group compared with those of control group (P < 0.01). There was no significant difference in the level of CETP hetween two groups, hut the level of CETP was negatively correlated with the levels of HDL-C and ApoAl (r,= -0.141 and r,= -0.165 ,P < 0.05). The multivari-ate logistic regression analysis showed that CETP level was not independent risk factors of CHD.Conclusion Although CETP was not influencing factors of coronary heart disease, this study provided clinical data for regulating hlood lipids and treatment of coronary heart disease hy the intervention of CETP.%目的 探讨血浆胆固醇酯转运蛋白(CETP)对冠心病(CHD)患者相关血脂指标的影响.方法 行冠状动脉造影的患者550例,根据冠状动脉造影结果分为CHD组(n=430)和正常组(n=120).测定2组血浆CETP、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)及ApoA1/ApoB水平.结果 CHD组患者血浆中HDL-C、ApoA1及ApoA1/ApoB的水平显著低于正常组(P < 0.01);CETP水平在CHD组与正常组间差异无统计学意义,CETP水平与HDL-C和ApoA1值呈负相关(rs分别为-0.141和-0.165,P < 0.05);多因素Logistic回归分析显示,CETP不是CHD的独立影响因素.结论 CETP虽然不是冠心病的影响因素,但是为以后通过干预CETP来调节血脂并治疗冠心病提供了一定的临床数据资料.
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