血管生成依赖于血管生成刺激因子和抑制因子之间的平衡。Vasohibin家族作为新近发现的血管生成调节因子，参与多种病理生理过程。其中Vasohibin-1是迄今为止发现的唯一以负反馈为作用机制调节血管生成的因子，可抑制血管生成；而Vasohibin-2促进血管生成，表达于肿瘤细胞和单核细胞；研究还发现了一个小分子的Vasohibin结合蛋白，其存在于内皮细胞，可与Vasohibin-1和Vasohibin-2结合，与Vasohibin-1结合时，增强抗血管生成的活性，扮演分泌伴侣作用。本文就Vasohibin家族成员的结构特点、生物活性及在抑制病理性血管生成中的作用作一综述。%Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. Vasohibin family as a novel regulator of angiogenesis involves in the process of various pathophysiology. Vasohibin-1 is the only factor that regulates angiogenesis by means of negative feedback as the mechanism of action. It is expressed in ECs to terminate an-giogenesis. Subsequently one gene homologous to vasohibin-1 was found and designated as vasohibin-2, which is expressed in infiltrating MNCs or cancer cells to stimulate angiogenesis. Furthermore, one binding protein to vasohibin-1 and vasohib-in-2 has been discovered and renamed as small vasohibin-binding protein (SVBP). The analysis of the function of SVBP has revealed that SVBP binds to vasohibin-1 within cells, makes a heterodimer with vasohibin-1 and facilitates the secretion of vasohibin-1. This article reviews the construction features and biological activities of vasohibin family members and their ef-fects of inhibiting pathology angiogenesis.
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